Yeah, got it running here. Still working out some kinks, but it works and is interesting. Though I haven't gotten any plug-ins running yet, so there's not much to manipulate or integrate. There's a Maya and Katana plug-in for I/O, with Houdini on the way.
Since it's CentOS only, it did put up some limitations on use personally, so I've been working on getting it working on any platform - including Windows - via Docker.
Here's how you can test out the Python interface currently if you've got access to Docker.
$ docker build -t mottosso/usd https://github.com/mottosso/docker-usd.git
$ docker run -ti -h usd --rm -v $(pwd):/home/root mottosso/usd
This will install USD and build it's dependencies; a process which takes about 5 hours. Yeah.. But once it's done, it'll boot up in less than a second each subsequent time.
Here's the repo.